Nutrition Insight

The Rise of Muscle-Centric Longevity and the Power of Akkermansia

Written by CJBIO | Dec 10, 2025 8:21:11 AM

The Age of Longevity
: Why Muscle Health Matters

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    Understanding Healthy Aging
     
     

     

     

    The concept of Healthy Aging is gaining significant attention across all age groups. As the term suggests, the goal is not just to extend lifespan but to ensure a physically, mentally, and socially fulfilling life [Figure 1].01

    According to an Innova report, 59% of consumers in the U.S. and Canada consider “healthy aging” to be very important, while 40% actively seek to improve their lifestyle to support this goal.02

     

    Figure 1. Four Main Elements of Healthy Aging

     

    • The Role of Muscle Health in the Healthy Aging Trend ​​


    Muscle health is a cornerstone of Healthy Aging, playing a crucial role in maintaining mobility, independence, and overall quality of life. However, preserving muscle mass and strength becomes increasingly challenging with age. Adults who do not engage in regular muscle-strengthening activities can lose approximately 4 to 6 pounds of muscle per decade.03
    The consequences of muscle loss extend beyond physical decline. It increases the risk of chronic diseases such as obesity and cancer04, raises the likelihood of falls and cognitive decline05, and contributes to financial burdens due to rising medical expenses06 [Figure 2]. In other words, muscle deterioration is a significant barrier to healthy aging.


    Traditionally, consumers have relied on exercise, protein supplementation, and mineral intake to counteract muscle loss.02 However, recent advancements in microbiome science are offering innovative new approaches to muscle health.

    Figure 2. Health Risks Resulting from Muscle Loss

     

  • Akkermansia Muciniphila
    : The Next-Gen Microbiome Solution for Muscle Health

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  • Consumers Searching for Scientifically Proven Solutions​​

 

Modern consumers prioritize clinically validated ingredients over simply preferring “natural” alternatives, aligning with the growing “Clinical over Clean” trend in consumer health.07 Interest in microbiome-based solutions has surged as scientific research continues to reveal the connection between gut microbiota and muscle health.

Among the many beneficial gut bacteria, Akkermansia muciniphila has emerged as a key player in supporting gut and metabolic health. Its effects on weight management, inflammation reduction, and metabolic disease prevention are being actively studied, fueling significant interest in global markets.08 According to Innova Database, the number of new product development (NPD) supplements containing Akkermansia has increased by an impressive 134.52% over the past two years (2022-2024) [Figure 3].09

Figure 3. 2Y CAGR (2022-2024) of NPD Supplements Containing Akkermansia

 

Regulatory Hurdles for Akkermansia-Based Products

Despite its promising potential, none of the currently available Akkermansia-based products have received New Dietary Ingredient Notification (NDIN) acknowledgment from the U.S. FDA.
This means their safety has not yet been officially verified under the NDIN framework, limiting their commercial application. However, the industry is now witnessing a significant breakthrough that is set to change the landscape.
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  1. McKinsey Health Institute, Living longer in better health: Six shifts needed for healthy aging, 2022.11
  2. Innova Report, Prioritizing Prevention: Consumer Action Toward Healthy Aging in the US & Canada, 2024.07
  3. Harvard Health Publishing, Muscle loss and protein needs in older adults, 2024.08
  4. FMCG Gurus, Fueling Health & Disease Management Opportunities in 2024
  5. Harvard Health Publishing, A guide to combating sarcopenia and preserving muscle mass as you get older, 2024.09
  6. Health Care Costs Associated With Muscle Weakness: A UK Population-Based Estimate, 2018.09
  7. McKinsey&Company, What is the future of wellness?, 2024.11
  8. Innova Report, The Gut Guardian - Akkermansia Muciniphila's Impact on Human Health – Global, 2023.12
  9. Innova Database, “Akkermansia” Supplements, 2022-2024